Premarin and Firazyr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Firazyr (icatibant acetate). Common drug interactions include hereditary angioedema among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Firazyr. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Firazyr?

Firazyr has active ingredients of icatibant acetate. eHealthMe is studying from 5,650 Firazyr users. Check the latest studies of Firazyr.



On Jul, 14, 2026

15 people who take Premarin and Firazyr together, and have interactions are studied.

Premarin and Firazyr drug interactions.

What are the common drug interactions of Premarin and Firazyr, by gender? *:

female:

  1. Hereditary angioedema (recurrent episodes of severe swelling)
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Vomiting
  4. Abdominal pain
  5. Decreased appetite
  6. Gastric disorder (disease of stomach)
  7. Pain
  8. Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
  9. Poor venous access
  10. Thrombosis (formation of a blood clot inside a blood vessel)

male:

n/a

What are the common drug interactions of Premarin and Firazyr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anxiety
  2. Aphonia (inability to produce voice)
  3. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  4. Blood pressure increased
  5. Burning sensation
  6. Chest discomfort
  7. Crying
  8. Dizziness
  9. Drug effect decreased
  10. Drug ineffective

50-59:

n/a

60+:

  1. Abdominal distension
  2. Cystitis (inflammation of the wall of the bladder)
  3. Hereditary angioedema (recurrent episodes of severe swelling)

What are the existing conditions these people have? *

  1. Hereditary Angioedema (recurrent episodes of severe swelling): 9 people, 60.00%
  2. Immune System Disorder: 5 people, 33.33%
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 13.33%
  4. Essential Hypertension (primary hypertension): 2 people, 13.33%
  5. Diabetes: 2 people, 13.33%
  6. Enzyme Abnormality: 1 person, 6.67%
  7. Complement Factor Abnormal: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and Firazyr?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Premarin and Firazyr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Firazyr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Premarin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Firazyr and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated and icatibant acetate (the active ingredients of Premarin and Firazyr, respectively), and Premarin and Firazyr (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: