Premarin and Marcaine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Marcaine (bupivacaine hydrochloride). Common drug interactions include muscular weakness among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Marcaine. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Marcaine?

Marcaine has active ingredients of bupivacaine hydrochloride. It is often used in pain. eHealthMe is studying from 4,026 Marcaine users. Check the latest studies of Marcaine.

On Jul, 13, 2026

12 people who take Premarin and Marcaine together, and have interactions are studied.

Premarin and Marcaine drug interactions.

What are the common drug interactions of Premarin and Marcaine, by gender? *:

female:

Muscular weakness (muscle weakness)
Weight decreased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Fungal infection
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Lumbar vertebral fracture
Palpitations (feelings or sensations that your heart is pounding or racing)
Pleural effusion (water on the lungs)
Pneumonia

male:

n/a

What are the common drug interactions of Premarin and Marcaine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Binocular eye movement disorder
Coma (state of unconsciousness lasting more than six hours)
Fungal infection
Hepatitis (inflammation of the liver)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Unevaluable reaction

60+:

Dysphagia (a condition in which swallowing is difficult or painful)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pleural effusion (water on the lungs)
Pulmonary embolism (blockage of the main artery of the lung)
Rib fracture
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Atrophic vulvovaginitis (inflammation of the vulva)
Cardiac arrest
Cardiomegaly (increased size of heart than normal)

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 33.33%
Neuropathy Peripheral (surface nerve damage): 4 people, 33.33%
Nerve Block (the interruption of signals travelling along a nerve): 4 people, 33.33%
Neck Pain: 4 people, 33.33%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 4 people, 33.33%
Muscle Spasms (muscle contraction): 4 people, 33.33%
Hypotonia (low muscle tone): 4 people, 33.33%
Headache (pain in head): 4 people, 33.33%
Analgesia: 4 people, 33.33%
Anaesthesia: 4 people, 33.33%

* Approximation only. Some reports may have incomplete information.

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