Premarin and Methyltestosterone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Methyltestosterone (methyltestosterone). Common drug interactions include arthritis among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Methyltestosterone. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Methyltestosterone?

Methyltestosterone has active ingredients of methyltestosterone. eHealthMe is studying from 352 Methyltestosterone users. Check the latest studies of Methyltestosterone.

On Jul, 12, 2026

54 people who take Premarin and Methyltestosterone together, and have interactions are studied.

Premarin and Methyltestosterone drug interactions.

What are the common drug interactions of Premarin and Methyltestosterone, by gender? *:

female:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Pain
Cough
Headache (pain in head)
Joint swelling
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)

male:

n/a

What are the common drug interactions of Premarin and Methyltestosterone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)

40-49:

Joint swelling
Kidney enlargement
Migraine (headache)
Migraine without aura (headache without neurological problems)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Pain
Pain in extremity

50-59:

Drug level increased
Electrocardiogram qt prolonged
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Depression
Ankle fracture
Cellulitis (infection under the skin)
Osteoporosis (bones weak and more likely to break)
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chronic kidney disease

60+:

Nausea (feeling of having an urge to vomit)
Ankle fracture
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pain
Peripheral swelling
Abnormal dreams
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)

What are the existing conditions these people have? *

Mood Swings (an extreme or rapid change in mood): 14 people, 25.93%
Fever: 14 people, 25.93%
Rashes (redness): 14 people, 25.93%
Insomnia (sleeplessness): 13 people, 24.07%
Asthma: 13 people, 24.07%
Hypersensitivity: 13 people, 24.07%
Abdominal Discomfort: 13 people, 24.07%
Pain: 12 people, 22.22%
The Flu (the flu is caused by an influenza virus): 9 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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