Premarin and Pennsaid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Pennsaid (diclofenac sodium). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Pennsaid. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

On Jul, 19, 2026

23 people who take Premarin and Pennsaid together, and have interactions are studied.

Premarin and Pennsaid drug interactions.

What are the common drug interactions of Premarin and Pennsaid, by gender? *:

female:

Fatigue (feeling of tiredness)
Dementia (madness)
Arthralgia (joint pain)
Atrophic vulvovaginitis (inflammation of the vulva)
Cough
Dysaesthesia (abnormal sensation)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperlipidaemia (presence of excess lipids in the blood)
Impaired fasting glucose

male:

n/a

What are the common drug interactions of Premarin and Pennsaid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Balance disorder
Diarrhoea
Drug hypersensitivity
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Paralysis
Vomiting

60+:

Dementia (madness)
Fatigue (feeling of tiredness)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired fasting glucose
Intervertebral disc degeneration (spinal disc degeneration)
Migraine (headache)
Neuritis (inflammation of nerve)
Pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 26.09%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 26.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 26.09%
Neuralgia (pain in one or more nerves): 6 people, 26.09%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 5 people, 21.74%
Osteoporosis (bones weak and more likely to break): 5 people, 21.74%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 21.74%
Essential Hypertension (primary hypertension): 5 people, 21.74%
Constipation: 4 people, 17.39%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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