Premarin and Renagel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Renagel (sevelamer hydrochloride). Common drug interactions include pain among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Renagel. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Renagel?

Renagel has active ingredients of sevelamer hydrochloride. eHealthMe is studying from 8,246 Renagel users. Check the latest studies of Renagel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

57 people who take Premarin and Renagel together, and have interactions are studied.

What are the common drug interactions of Premarin and Renagel, by gender? *:

female:

Pain
Oedema peripheral (superficial swelling)
Hypoaesthesia (reduced sense of touch or sensation)
Muscular weakness (muscle weakness)
Dysphagia (a condition in which swallowing is difficult or painful)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Mobility decreased (ability to move is reduced)
Adrenal neoplasm (abnormal growth of adrenal gland)
Ankle fracture
Arthralgia (joint pain)

male:

n/a

What are the common drug interactions of Premarin and Renagel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac arrest
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Renal failure chronic (long lasting kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Unresponsive to stimuli
Bacteraemia (presence of bacteria in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhage (bleeding)
Staphylococcal bacteraemia (a bacterial infection of blood)

50-59:

Anxiety
Deformity (disfigurement)
Infection
Injury
Tooth extraction
Disability
Neuropathy peripheral (surface nerve damage)
Bone neoplasm (tumour of bone)
Vascular pseudoaneurysm (leakage of arterial blood from an artery into the surrounding tissue with a continuing communication between the originating artery and the resultant adjacent cavity)
Skin erosion (a discontinuity of the skin)

60+:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Renal failure acute (rapid kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sinusitis (inflammation of sinus)
Tinnitus (a ringing in the ears)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 13 people, 22.81%
Light Chain Analysis Increased: 12 people, 21.05%
Neoplasm Malignant (cancer tumour): 9 people, 15.79%
Hypertensive Heart Disease: 3 people, 5.26%
Chronic Renal Failure (kidney failure): 3 people, 5.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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