Premarin and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Rocephin (ceftriaxone sodium). Common drug interactions include nausea among females and abscess jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Rocephin. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

On Jul, 16, 2026

79 people who take Premarin and Rocephin together, and have interactions are studied.

Premarin and Rocephin drug interactions.

What are the common drug interactions of Premarin and Rocephin, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Injury
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Osteoporosis (bones weak and more likely to break)
Anaemia (lack of blood)
Cardiomegaly (increased size of heart than normal)
Fall
Pyrexia (fever)
Vomiting

male:

Abscess jaw (tooth abscess or root abscess)
Anaemia of chronic disease
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Brain injury
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Premarin and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess jaw (tooth abscess or root abscess)
Anaemia of chronic disease
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Back pain

30-39:

n/a

40-49:

Blindness
Blood cholesterol increased
Blood potassium increased
Cardiomyopathy (weakening of the heart muscle)
Carotid bruit (sound heard over the carotid artery area during auscultation)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic nephropathy (diabetic kidney disease)

50-59:

Blood amylase increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coma (state of unconsciousness lasting more than six hours)
Drug ineffective
Drug toxicity
Fall
Fear, focus
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Haemosiderosis (general increase in tissue iron stores without associated tissue damage)
Head injury

60+:

Pain
Fatigue (feeling of tiredness)
Pyrexia (fever)
Spinal compression fracture (fracture due to spinal compression on bone)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dyspnoea (difficult or laboured respiration)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inflammation
Migraine (headache)
Osteonecrosis of jaw (death of bone of jaw)

What are the existing conditions these people have? *

Pain: 6 people, 7.59%
Osteolysis (dissolution of bone): 5 people, 6.33%
High Blood Pressure: 5 people, 6.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.33%
Cardiac Disorder: 5 people, 6.33%
Resorption Bone Increased: 4 people, 5.06%
Nausea (feeling of having an urge to vomit): 4 people, 5.06%
Cardiac Failure Congestive: 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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