Premarin and Tirosint drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Tirosint (levothyroxine sodium). Common drug interactions include ear pain among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Tirosint. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Tirosint?

Tirosint has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 5,001 Tirosint users. Check the latest studies of Tirosint.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

31 people who take Premarin and Tirosint together, and have interactions are studied.

Premarin and Tirosint drug interactions.

What are the common drug interactions of Premarin and Tirosint, by gender? *:

female:

Ear pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Irritable bowel syndrome
Neoplasm malignant (cancer tumour)
Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain in extremity
Pancreatic disorder
Skin cancer
Thyroid disorder (thyroid diseases)

male:

n/a

What are the common drug interactions of Premarin and Tirosint, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Back pain
Blood pressure increased
Diarrhoea
Heart rate decreased
Hypopnoea (decrease in the breathing rate)
Kidney infection
Peripheral swelling
Renal disorder (kidney disease)
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Adrenal disorder

50-59:

Asthenia (weakness)
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Muscular weakness (muscle weakness)
Peripheral swelling
Respiratory tract infection fungal
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Aphonia (inability to produce voice)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Irritable bowel syndrome
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neoplasm malignant (cancer tumour)
Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain in extremity
Pancreatic disorder
Skin cancer

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 19.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 16.13%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 4 people, 12.90%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 6.45%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 6.45%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 6.45%
Drowsiness: 2 people, 6.45%
Depression: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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