Premphase 14/14 and Prozac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premphase 14/14 (estrogens, conjugated; medroxyprogesterone acetate) and Prozac (fluoxetine hydrochloride). Common drug interactions include anaemia among females.

The phase IV clinical study analyzes what interactions people have when they take Premphase 14/14 and Prozac. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Premphase 14/14?

Premphase 14/14 has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 1,114 Premphase 14/14 users. Check the latest studies of Premphase 14/14.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

On Aug, 10, 2026

12 people who take Premphase 14/14 and Prozac together, and have interactions are studied.

Premphase 14/14 and Prozac drug interactions.

What are the common drug interactions of Premphase 14/14 and Prozac, by gender? *:

female:

Anaemia (lack of blood)
Arthropathy
Pericardial effusion (fluid around the heart)
Abdominal pain
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Breast cancer
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Osteoporosis (bones weak and more likely to break)
Asthenia (weakness)

male:

n/a

What are the common drug interactions of Premphase 14/14 and Prozac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Arthropathy
Cardiac disorder
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Mitral valve incompetence (inefficient heart valve)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Pericardial effusion (fluid around the heart)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)

50-59:

Depression suicidal (suicide depressive disorder)
Dyspareunia (painful sexual intercourse)
Endometrial hypertrophy (enlargement of uterine wall from the increase in size of its cells)
Exostosis (formation of new bone on the surface of a bone)
Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Neck pain

60+:

Breast cancer female
Catheter site cellulitis (infection of cells near catheter)
Hot flush (sudden feelings of heat)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 33.33%
Stress And Anxiety: 3 people, 25.00%
Menopause (end of monthly cycles in women): 3 people, 25.00%
Vulvovaginal Dryness: 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Asthma: 2 people, 16.67%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 8.33%
Mood Swings (an extreme or rapid change in mood): 1 person, 8.33%
Hypersensitivity: 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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