Prempro and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate) and Colace (docusate ). Common drug interactions include asthenia among females.

The phase IV clinical study analyzes what interactions people have when they take Prempro and Colace. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

On Jul, 18, 2026

79 people who take Prempro and Colace together, and have interactions are studied.

What are the common drug interactions of Prempro and Colace, by gender? *:

female:

Asthenia (weakness)
Burning sensation
Fatigue (feeling of tiredness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Blood triglycerides increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal failure (kidney dysfunction)

male:

n/a

What are the common drug interactions of Prempro and Colace, by age (0-1 to 60+)? *:

0-1:

Injection site oedema
Pain in limb
Thrombosis (formation of a blood clot inside a blood vessel)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Acute respiratory distress syndrome
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anisocytosis (patient's red blood cells are of unequal size)
Anxiety
Asthenia (weakness)
Back pain
Beta 2 microglobulin increased
Blood calcium decreased
Blood glucose increased

40-49:

Blood glucose increased
Diarrhoea
Feeling drunk
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Sleep paralysis (waking up and unable to move or speak)
Vomiting
Abdominal discomfort
Abdominal distension
Abdominal hernia

50-59:

Oedema peripheral (superficial swelling)
Pain in extremity
Pleural effusion (water on the lungs)
Pneumonia
Spinal osteoarthritis (joint cartilage loss in spine)
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Anaemia (lack of blood)
Aortic bruit (unusual sound that blood makes when it rushes past an obstruction in aortic artery)
Arteriosclerosis (thickening and hardening of arteries)

60+:

Drug ineffective
Hallucination (an experience involving the perception of something not present)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Suicidal ideation
Syncope (loss of consciousness with an inability to maintain postural tone)
Thrombocytopenia (decrease of platelets in blood)
Dehydration (dryness resulting from the removal of water)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Chronic kidney disease
Dizziness

What are the existing conditions these people have? *

Pain: 8 people, 10.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.86%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.33%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.33%
Osteoporosis (bones weak and more likely to break): 4 people, 5.06%
Menopausal Symptoms: 4 people, 5.06%
Depression: 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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