Prempro and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate) and Linzess (linaclotide). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Prempro and Linzess. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

23 people who take Prempro and Linzess together, and have interactions are studied.

What are the common drug interactions of Prempro and Linzess, by gender? *:

female:

Fatigue (feeling of tiredness)
Weight decreased
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Urinary tract infection
Vaginal discharge
Vulvovaginal burning sensation
Vulvovaginal discomfort
Vulvovaginal pruritus (vulvovaginal severe itching)
Vulvovaginal swelling

male:

n/a

What are the common drug interactions of Prempro and Linzess, by age (0-1 to 60+)? *:

0-1:

Vulvovaginal disorder

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Borderline glaucoma
Glaucoma (increased fluid pressure in the eye with vision loss)
Herpes zoster
Immune system disorder
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Soft tissue disorder (disease of soft tissue)

40-49:

Anaphylactic reaction (serious allergic reaction)
Capillary fragility (lack in resistance of capillary)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hypersensitivity
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Adverse reaction
Alopecia (absence of hair from areas of the body)

50-59:

Weight decreased
Back pain
Chills (felling of cold)
Dizziness
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Feeling hot
Hot flush (sudden feelings of heat)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

60+:

Headache (pain in head)
Inflammatory bowel disease
Hypertension (high blood pressure)
Infection
Pain in extremity
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Influenza

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 39.13%
Irritable Bowel Syndrome: 7 people, 30.43%
Fluid Retention (an abnormal accumulation of fluid in the blood): 6 people, 26.09%
Hypersensitivity: 5 people, 21.74%
Sleep Disorder: 5 people, 21.74%
Diabetes: 5 people, 21.74%
Seasonal Allergy (allergic condition due to certain season): 4 people, 17.39%
Asthma: 4 people, 17.39%
Pain: 4 people, 17.39%
Migraine (headache): 4 people, 17.39%

* Approximation only. Some reports may have incomplete information.

Do you take Prempro and Linzess?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously