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Prempro and Tofranil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate) and Tofranil (imipramine hydrochloride). Common drug interactions include insomnia among females.

The phase IV clinical study analyzes what interactions people have when they take Prempro and Tofranil. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

On Aug, 01, 2026

13 people who take Prempro and Tofranil together, and have interactions are studied.

Prempro and Tofranil drug interactions.

What are the common drug interactions of Prempro and Tofranil, by gender? *:

female:

  1. Insomnia (sleeplessness)
  2. Anxiety disorder
  3. Headache (pain in head)
  4. Hypercholesterolaemia (high levels of cholesterol in the blood)
  5. Hypertriglyceridaemia (excess of triglycerides in the blood)
  6. Memory impairment
  7. Mitral valve incompetence (inefficient heart valve)
  8. Morbid thoughts (serious thoughts)
  9. Presbyacusis (age-related hearing loss)
  10. Tricuspid valve incompetence (inefficient heart valve)

male:

n/a

What are the common drug interactions of Prempro and Tofranil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Thyroid disorder (thyroid diseases)
  2. Agitation (state of anxiety or nervous excitement)
  3. Constipation
  4. Drug hypersensitivity
  5. Flatulence (flatus expelled through the anus)
  6. Insomnia (sleeplessness)
  7. Panic attack
  8. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

60+:

  1. Anxiety disorder
  2. Asthenia (weakness)
  3. Hypercholesterolaemia (high levels of cholesterol in the blood)
  4. Hypertriglyceridaemia (excess of triglycerides in the blood)
  5. Insomnia (sleeplessness)
  6. Memory impairment
  7. Mitral valve incompetence (inefficient heart valve)
  8. Morbid thoughts (serious thoughts)
  9. Presbyacusis (age-related hearing loss)
  10. Tricuspid valve incompetence (inefficient heart valve)

What are the existing conditions these people have? *

  1. Exostosis (formation of new bone on the surface of a bone): 3 people, 23.08%
  2. Joint Pain: 1 person, 7.69%
  3. High Blood Cholesterol: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Prempro and Tofranil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prempro and Tofranil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prempro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tofranil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prempro and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tofranil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate and imipramine hydrochloride (the active ingredients of Prempro and Tofranil, respectively), and Prempro and Tofranil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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