Prezista and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prezista (darunavir ethanolate) and Actos (pioglitazone hydrochloride). Common drug interactions include hyperphosphataemia among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Prezista and Actos. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Prezista?

Prezista has active ingredients of darunavir ethanolate. It is often used in hiv infection. eHealthMe is studying from 12,363 Prezista users. Check the latest studies of Prezista.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Aug, 01, 2026

39 people who take Prezista and Actos together, and have interactions are studied.

What are the common drug interactions of Prezista and Actos, by gender? *:

female:

Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Insomnia (sleeplessness)
Mobility decreased (ability to move is reduced)
Pain in extremity
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Stress
Upper limb fracture
Chronic kidney disease
Emotional distress

male:

Blood glucose increased
Emotional distress
Renal failure (kidney dysfunction)
Abdominal pain upper
Drug ineffective
Renal disorder (kidney disease)
Depression
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Decreased activity

What are the common drug interactions of Prezista and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood glucose increased
Hyperlipidaemia (presence of excess lipids in the blood)
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Depression
Emotional distress
Fatigue (feeling of tiredness)

40-49:

Lower limb fracture
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Pain
Spinal fracture (fracture in one of vertebrae)
Chronic kidney disease
Femur fracture

50-59:

Chronic kidney disease
Drug ineffective
Nausea (feeling of having an urge to vomit)
Emotional distress
Mobility decreased (ability to move is reduced)
Pain
Renal failure (kidney dysfunction)
Abdominal pain upper
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

60+:

Abdominal pain upper
Eructation (release of gas from the digestive tract)
Dysuria (painful or difficult urination)
Emotional distress
Gait disturbance
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Osteoporosis (bones weak and more likely to break)
Pain

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 25.64%
High Blood Cholesterol: 8 people, 20.51%
Depression: 5 people, 12.82%
Pain: 4 people, 10.26%
Osteoporosis (bones weak and more likely to break): 4 people, 10.26%
Neuropathy Peripheral (surface nerve damage): 4 people, 10.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.26%
Type 2 Diabetes: 3 people, 7.69%
Herpes Simplex (herpes simplex is a common viral infection): 3 people, 7.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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