Prilosec and Valproic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prilosec (omeprazole) and Valproic acid (valproic acid). Common drug interactions include type 2 diabetes mellitus among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Prilosec and Valproic acid. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,286 Prilosec users. Check the latest studies of Prilosec.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

95 people who take Prilosec and Valproic acid together, and have interactions are studied.

Prilosec and Valproic acid drug interactions.

What are the common drug interactions of Prilosec and Valproic Acid, by gender? *:

female:

Type 2 diabetes mellitus
Anticonvulsant drug level increased
Joint injury
Renal injury (kidney injury)
Hyperkalaemia (damage to or disease of the kidney)
Vomiting
Blood cholesterol increased
Death
Lipids increased (excess lipid in body)
Lower limb fracture

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Anxiety
Arthropathy
Coeliac disease (simple food intolerance)
Exercise tolerance decreased

What are the common drug interactions of Prilosec and Valproic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Pancreatitis (inflammation of pancreas)
Pharyngeal erythema (pharyngeal redness)
Vomiting

10-19:

Nausea (feeling of having an urge to vomit)
Retching (strong involuntary effort to vomit)
Salivary hypersecretion (excess saliva secretion)
Bezoar (mass found trapped in the gastrointestinal system)
Gastrointestinal obstruction
Intestinal obstruction
Vomiting
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

20-29:

Granulocytopenia (lack of granulocyte)

30-39:

Ill-defined disorder
Type 2 diabetes mellitus
Blood creatine phosphokinase increased
Blood glucose increased
Blood lactate dehydrogenase increased
Depression
Diarrhoea
Hypersensitivity
Myositis (inflammation of the muscles)
Rash generalised (rash on most of body parts)

40-49:

Renal failure (kidney dysfunction)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Fall
Anticonvulsant drug level increased
Gait disturbance
Joint injury
Blood cholesterol increased
Diarrhoea
Lipids increased (excess lipid in body)

50-59:

Dizziness
Dysarthria (speech disorder)
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye pain
Febrile neutropenia (fever with reduced white blood cells)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Hypertension (high blood pressure)

60+:

Pneumonia
Asthenia (weakness)
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Ascites (accumulation of fluid in the abdominal cavity)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Blood cholesterol increased
Blood pressure systolic decreased
Bradycardia (abnormally slow heart action)

What are the existing conditions these people have? *

Pain: 19 people, 20.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 12 people, 12.63%
High Blood Cholesterol: 12 people, 12.63%
High Blood Pressure: 11 people, 11.58%
Bipolar Disorder (mood disorder): 9 people, 9.47%
Gout (uric acid crystals building up in the body): 7 people, 7.37%
Depression: 7 people, 7.37%
Oedema (fluid collection in tissue): 6 people, 6.32%
Infection: 6 people, 6.32%
Angiomyolipoma (most common benign tumour of the kidney): 6 people, 6.32%

* Approximation only. Some reports may have incomplete information.

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