Primaxin and Aciphex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primaxin (cilastatin sodium; imipenem) and Aciphex (rabeprazole sodium). Common drug interactions include abdominal distension among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Primaxin and Aciphex. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Primaxin?

Primaxin has active ingredients of cilastatin sodium; imipenem. eHealthMe is studying from 4,540 Primaxin users. Check the latest studies of Primaxin.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

On Jul, 29, 2026

21 people who take Primaxin and Aciphex together, and have interactions are studied.

What are the common drug interactions of Primaxin and Aciphex, by gender? *:

female:

Abdominal distension
Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

male:

Pyrexia (fever)
Wound dehiscence (a surgical incision reopens either internally or externally)
Anxiety
Balanitis (inflammation of the glands penis)
Benign oesophageal neoplasm (benign (non-cancerous) tumours of the oesophageal)
Bladder diverticulum (pouch like projection in the bladder, by birth or acquired)
Blood testosterone decreased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone swelling
Cough

What are the common drug interactions of Primaxin and Aciphex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal distension
Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

20-29:

n/a

30-39:

n/a

40-49:

Lethargy (tiredness)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)
Wound dehiscence (a surgical incision reopens either internally or externally)
Wound infection
Abscess (pus)
Corynebacterium infection (infection by corynebacterium (diphtheria))
Dysphagia (a condition in which swallowing is difficult or painful)
Faecal impaction

50-59:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Vertigo
Vomiting

60+:

Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone swelling
Cough
Dental fistula
Disability
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)

What are the existing conditions these people have? *

Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 16 people, 76.19%
Gynecomastia (enlargement of the gland tissue of the male breast): 16 people, 76.19%
Osteopenia (a condition where bone mineral density is lower than normal): 14 people, 66.67%

* Approximation only. Some reports may have incomplete information.

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