Primidone and Esbriet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primidone (primidone) and Esbriet (pirfenidone). Common drug interactions include malaise among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Primidone and Esbriet. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

What is Esbriet?

Esbriet has active ingredients of pirfenidone. eHealthMe is studying from 39,858 Esbriet users. Check the latest studies of Esbriet.

On Jul, 27, 2026

51 people who take Primidone and Esbriet together, and have interactions are studied.

Primidone and Esbriet drug interactions.

What are the common drug interactions of Primidone and Esbriet, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Rhinorrhoea (watery mucus discharge from the nose)
Sneezing
Abdominal pain upper
Blood pressure increased
Bradycardia (abnormally slow heart action)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Injection site extravasation (flow of (blood or lymph) from injection site)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

male:

Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)
Weight decreased
Abdominal discomfort
Gastric disorder (disease of stomach)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Rash
Asthenia (weakness)
Arthralgia (joint pain)
Decreased appetite

What are the common drug interactions of Primidone and Esbriet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood pressure increased
Bradycardia (abnormally slow heart action)
Hypotension (abnormally low blood pressure)
Injection site extravasation (flow of (blood or lymph) from injection site)
Malaise (a feeling of general discomfort or uneasiness)
Weight decreased

60+:

Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)
Mass
Rash
Diarrhoea
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Abdominal discomfort
Asthenia (weakness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Idiopathic Pulmonary Fibrosis (chronic lung disease): 35 people, 68.63%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 17.65%
Interstitial Lung Disease: 5 people, 9.80%

* Approximation only. Some reports may have incomplete information.

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