Primidone and Opana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primidone (primidone) and Opana (oxymorphone hydrochloride). Common drug interactions include cough among females and psoriasis among males.

The phase IV clinical study analyzes what interactions people have when they take Primidone and Opana. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

What is Opana?

Opana has active ingredients of oxymorphone hydrochloride. It is often used in pain. eHealthMe is studying from 40,340 Opana users. Check the latest studies of Opana.



On Jul, 15, 2026

11 people who take Primidone and Opana together, and have interactions are studied.

Primidone and Opana drug interactions.

What are the common drug interactions of Primidone and Opana, by gender? *:

female:

  1. Cough
  2. Drug abuse
  3. Drug ineffective
  4. Fatigue (feeling of tiredness)
  5. Neutropenia (an abnormally low number of neutrophils)
  6. Weight decreased
  7. Dyspnoea (difficult or laboured respiration)
  8. Extrasystoles
  9. Oxygen consumption increased
  10. Spinal fusion surgery

male:

  1. Psoriasis (immune-mediated disease that affects the skin)
  2. Drug hypersensitivity
  3. Vision blurred
  4. Rash papular (redness with papule)
  5. Vertigo
  6. Hypoaesthesia (reduced sense of touch or sensation)
  7. Parkinson's disease
  8. Peripheral swelling
  9. Rash erythematous (redness of the skin)
  10. Rash pruritic (redness with itching)

What are the common drug interactions of Primidone and Opana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Dyspnoea (difficult or laboured respiration)
  2. Extrasystoles
  3. Oxygen consumption increased

60+:

  1. Psoriasis (immune-mediated disease that affects the skin)
  2. Cough
  3. Peripheral swelling
  4. Rash erythematous (redness of the skin)
  5. Rash pruritic (redness with itching)
  6. Drug abuse
  7. Drug hypersensitivity
  8. Drug ineffective
  9. Fatigue (feeling of tiredness)
  10. Neutropenia (an abnormally low number of neutrophils)

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 4 people, 36.36%
  2. Stress And Anxiety: 2 people, 18.18%
  3. High Blood Cholesterol: 2 people, 18.18%
  4. Cardiac Disorder: 2 people, 18.18%
  5. Depression: 2 people, 18.18%
  6. Dry Eyes (lack of adequate tears): 2 people, 18.18%
  7. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 18.18%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
  9. High Blood Pressure: 2 people, 18.18%
  10. Hypersensitivity: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Primidone and Opana?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Primidone and Opana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Primidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Opana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Primidone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Opana and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on primidone and oxymorphone hydrochloride (the active ingredients of Primidone and Opana, respectively), and Primidone and Opana (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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