Primidone and Rufinamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primidone (primidone) and Rufinamide (rufinamide). Common drug interactions include seizure among females and anger among males.

The phase IV clinical study analyzes what interactions people have when they take Primidone and Rufinamide. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

What is Rufinamide?

Rufinamide has active ingredients of rufinamide. eHealthMe is studying from 946 Rufinamide users. Check the latest studies of Rufinamide.

On Jul, 26, 2026

19 people who take Primidone and Rufinamide together, and have interactions are studied.

Primidone and Rufinamide drug interactions.

What are the common drug interactions of Primidone and Rufinamide, by gender? *:

female:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Asthenia (weakness)
Body temperature increased
Fall
Hospitalisation
Hypersomnia (excessive daytime sleepiness (eds))
Nasopharyngitis (inflammation of the nasopharynx)
Overdose
Regressive behaviour (immature behaviour to ventilate feelings)
Renal disorder (kidney disease)

male:

Anger
Stereotypy (excessive repetition or lack of variation in movements, ideas, or patterns of speech)
Sedation
Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it)
Walking disability
Abulia (lack of will or initiative)
Decreased appetite
Drug resistance (reduction in effectiveness of a drug)
Generalised oedema (swelling all over the body)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)

What are the common drug interactions of Primidone and Rufinamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Renal disorder (kidney disease)

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Aggression
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abulia (lack of will or initiative)
Decreased appetite
Generalised oedema (swelling all over the body)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Salivary hypersecretion (excess saliva secretion)

30-39:

Drug resistance (reduction in effectiveness of a drug)
Sedation

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 7 people, 36.84%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 31.58%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 15.79%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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