Primrose and Letrozole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Primrose (evening primrose oil) and Letrozole (letrozole). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Primrose and Letrozole. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Primrose?

Primrose has active ingredients of evening primrose oil. It is often used in hair loss. eHealthMe is studying from 2,314 Primrose users. Check the latest studies of Primrose.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

On Aug, 04, 2026

54 people who take Primrose and Letrozole together, and have interactions are studied.

Primrose and Letrozole drug interactions.

What are the common drug interactions of Primrose and Letrozole, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Sinusitis (inflammation of sinus)
Arthralgia (joint pain)
Back pain
Breast cancer female
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Hypokalaemia (low potassium)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

male:

n/a

What are the common drug interactions of Primrose and Letrozole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nail hypertrophy (overgrowth or thickening of the nail)
Secondary progressive multiple sclerosis (a stage of ms which comes after relapsing remitting ms in many cases)
Uterine cancer
Neoplasm malignant (cancer tumour)

40-49:

n/a

50-59:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Fatigue (feeling of tiredness)
Abdominal pain
Extravasation (leakage of a fluid)
Mass
Nail disorder (disease of nail)
Neuropathy peripheral (surface nerve damage)
Pain
Skin ulcer

60+:

Fatigue (feeling of tiredness)
Headache (pain in head)
Sinus disorder (disease of sinus)
Weight decreased
Neutropenia (an abnormally low number of neutrophils)
Red blood cell count decreased
White blood cell count decreased
Decreased appetite
Drug ineffective
Joint swelling

What are the existing conditions these people have? *

Breast Cancer Metastatic: 38 people, 70.37%
Stomatitis (inflammation of mucous membrane of mouth): 20 people, 37.04%
Rashes (redness): 20 people, 37.04%
Oral Herpes (viral infection of mouth): 20 people, 37.04%
Diarrhea: 12 people, 22.22%
Immunodeficiency: 5 people, 9.26%
Breast Cancer Female: 4 people, 7.41%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.56%
Headache (pain in head): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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