Prinivil and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinivil (lisinopril) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include temperature intolerance among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Prinivil and Valacyclovir. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Prinivil?

Prinivil has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 20,152 Prinivil users. Check the latest studies of Prinivil.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.



On Jul, 12, 2026

30 people who take Prinivil and Valacyclovir together, and have interactions are studied.

Prinivil and Valacyclovir drug interactions.

What are the common drug interactions of Prinivil and Valacyclovir, by gender? *:

female:

  1. Temperature intolerance (inability to go in temperature)
  2. Tongue neoplasm malignant stage unspecified
  3. Urinary tract infection
  4. Drug hypersensitivity
  5. Fatigue (feeling of tiredness)
  6. Pain
  7. Abdominal pain
  8. Adverse event
  9. Angioedema (rapid swelling of the dermis)
  10. Anxiety

male:

  1. Renal failure (kidney dysfunction)
  2. Osteonecrosis (death of bone)
  3. Bone loss
  4. Chronic kidney disease
  5. Depression
  6. Fear
  7. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  8. Knee arthroplasty
  9. Migraine (headache)
  10. Multiple fractures

What are the common drug interactions of Prinivil and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Drug ineffective
  2. Premature delivery

30-39:

  1. Osteonecrosis (death of bone)
  2. Hip arthroplasty
  3. Bone density decreased
  4. Bone loss
  5. Chronic kidney disease
  6. Knee arthroplasty
  7. Multiple fractures
  8. Osteopenia (a condition where bone mineral density is lower than normal)
  9. Renal failure (kidney dysfunction)
  10. Rib fracture

40-49:

  1. Pain
  2. Adverse event
  3. Anxiety
  4. Back pain
  5. Blood glucose increased
  6. Blood urea nitrogen/creatinine ratio increased
  7. Depressed mood
  8. Diabetes mellitus inadequate control
  9. Drug hypersensitivity
  10. Drug intolerance (drug sensitivity)

50-59:

  1. Renal failure (kidney dysfunction)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Anxiety
  4. Depression
  5. Emotional distress
  6. Fatigue (feeling of tiredness)
  7. Fear
  8. Migraine (headache)
  9. Mobility decreased (ability to move is reduced)
  10. Pain

60+:

  1. Drug hypersensitivity
  2. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  3. Hypokalaemia (low potassium)
  4. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  5. Infection
  6. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  7. Neck pain
  8. Nephrogenic anaemia (anaemia due to kidney disease)
  9. Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
  10. Pancreatic carcinoma (pancreatic cancer)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 8 people, 26.67%
  2. Hiv Infection: 4 people, 13.33%
  3. Pain: 3 people, 10.00%
  4. Insomnia (sleeplessness): 2 people, 6.67%
  5. Diabetes: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Prinivil and Valacyclovir?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prinivil and Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prinivil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prinivil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valacyclovir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on lisinopril and valacyclovir hydrochloride (the active ingredients of Prinivil and Valacyclovir, respectively), and Prinivil and Valacyclovir (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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