Prinzide and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinzide (hydrochlorothiazide; lisinopril) and Leflunomide (leflunomide). Common drug interactions include asthenia among females and joint effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Prinzide and Leflunomide. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jun, 13, 2026

15 people who take Prinzide and Leflunomide together, and have interactions are studied.

Prinzide and Leflunomide drug interactions.

What are the common drug interactions of Prinzide and Leflunomide, by gender? *:

female:

Asthenia (weakness)
Weight decreased
Headache (pain in head)
Sinusitis (inflammation of sinus)
Confusional state
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Rash
Vomiting

male:

Joint effusion (presence of extra fluid in joint covering)
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)
Skin burning sensation
Cough
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Prinzide and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cough
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Cellulitis (infection under the skin)
Drug ineffective

60+:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Arthropathy
Bronchial infection
Confusional state
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 6.67%
Pain: 1 person, 6.67%
Osteoporosis (bones weak and more likely to break): 1 person, 6.67%
Muscle Spasms (muscle contraction): 1 person, 6.67%
Lipids Increased (excess lipid in body): 1 person, 6.67%
Joint Pain: 1 person, 6.67%
Gastric Ulcer (stomach ulcer): 1 person, 6.67%
Diabetes: 1 person, 6.67%
Depression: 1 person, 6.67%
Cellulitis (infection under the skin): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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