Prinzide and Lortab drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinzide (hydrochlorothiazide; lisinopril) and Lortab (acetaminophen; hydrocodone bitartrate). Common drug interactions include constipation among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Prinzide and Lortab. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

On Jul, 15, 2026

21 people who take Prinzide and Lortab together, and have interactions are studied.

What are the common drug interactions of Prinzide and Lortab, by gender? *:

female:

Constipation
Depression
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspnoea (difficult or laboured respiration)
Enthesopathy (disorder of entheses (bone attachments))
Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)
Femur fracture
Fibromyalgia (a long-term condition which causes pain all over the body)

male:

Gait disturbance
Memory impairment
Drug ineffective
Dysarthria (speech disorder)
Fall
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)

What are the common drug interactions of Prinzide and Lortab, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Nephrolithiasis (calculi in the kidneys)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)

40-49:

Headache (pain in head)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Drug hypersensitivity
Dysarthria (speech disorder)

50-59:

Vasculitis (inflammation of a blood vessel or blood vessels)
Vision blurred
Abdominal pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza
Intervertebral disc degeneration (spinal disc degeneration)

60+:

Drug ineffective
Fall
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chondropathy (disease of the cartilage)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery stenosis (narrowing of coronary artery)
Drug hypersensitivity
Epistaxis (bleed from the nose)
Essential hypertension (primary hypertension)

What are the existing conditions these people have? *

Type 2 Diabetes: 3 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 3 people, 14.29%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 9.52%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Muscle Spasms (muscle contraction): 2 people, 9.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 9.52%
Multiple Allergies (allergy to multiple agents): 2 people, 9.52%
Hypertensive Heart Disease: 2 people, 9.52%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 9.52%
Headache (pain in head): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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