Prinzide and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinzide (hydrochlorothiazide; lisinopril) and Pepcid (famotidine). Common drug interactions include gait disturbance among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Prinzide and Pepcid. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 11, 2026

41 people who take Prinzide and Pepcid together, and have interactions are studied.

What are the common drug interactions of Prinzide and Pepcid, by gender? *:

female:

Gait disturbance
Limb discomfort (discomfort in leg)
Migraine (headache)
Multi-organ failure (multisystem organ failure)
Oedema (fluid collection in tissue)
Pain
Renal injury (kidney injury)
Ankle fracture
Bankruptcy
Bladder infection

male:

Renal failure acute (rapid kidney dysfunction)
Back pain
Multi-organ failure (multisystem organ failure)
Neoplasm malignant (cancer tumour)
Abdominal pain
Arthralgia (joint pain)
Blood glucose increased
Blood in stool
Cardiac failure congestive
Chronic kidney disease

What are the common drug interactions of Prinzide and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood in stool
Haematocrit decreased
Haemoglobin decreased
Migraine (headache)
Platelet count decreased
Pyrexia (fever)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Laryngitis (inflammation of the larynx)
Pruritus (severe itching of the skin)

50-59:

Glomerular filtration rate decreased
Multiple fractures
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Osteoporosis (bones weak and more likely to break)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Respiratory tract congestion (blockage on respiratory system)
Swelling face

60+:

Diarrhoea
Back pain
Gastric infection (infection of stomach)
Hyperkalaemia (damage to or disease of the kidney)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Rash

What are the existing conditions these people have? *

Pain: 8 people, 19.51%
High Blood Cholesterol: 6 people, 14.63%
Diabetes: 6 people, 14.63%
Depression: 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 5 people, 12.20%
Motion Sickness (travel sickness): 4 people, 9.76%
Malignant Melanoma (skin cancer rises from melancytes): 4 people, 9.76%
Leukaemia (blood or bone marrow cancer): 4 people, 9.76%
Infection: 4 people, 9.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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