Prinzide and Roxicodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinzide (hydrochlorothiazide; lisinopril) and Roxicodone (oxycodone hydrochloride). Common drug interactions include homeless among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Prinzide and Roxicodone. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Roxicodone?

Roxicodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 20,099 Roxicodone users. Check the latest studies of Roxicodone.

On Jul, 08, 2026

28 people who take Prinzide and Roxicodone together, and have interactions are studied.

Prinzide and Roxicodone drug interactions.

What are the common drug interactions of Prinzide and Roxicodone, by gender? *:

female:

Homeless
Hyperhidrosis (abnormally increased sweating)
Hyporeflexia (a condition of below normal or absent reflexes)
Insomnia (sleeplessness)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Migraine (headache)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)

male:

Asthenia (weakness)
Blood creatinine increased
Colitis (inflammation of colon)
Confusional state
Death
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)

What are the common drug interactions of Prinzide and Roxicodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Upper respiratory tract infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased appetite
Fatigue (feeling of tiredness)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Chronic kidney disease
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Overdose
Shock hypoglycaemic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to less sugar in body)
Acute respiratory failure
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Asthenia (weakness)
Cardiac arrest

60+:

Anaemia (lack of blood)
Anxiety
Injury
Intervertebral disc disorder (spinal disc disorder)
Leukopenia (less number of white blood cells in blood)
Lumbar vertebral fracture
Multiple myeloma (cancer of the plasma cells)
Myalgia (muscle pain)
Neurofibroma (non-cancerous tumours that grow on nerves throughout the body)
Neuropathy peripheral (surface nerve damage)

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 17 people, 60.71%
Diabetes: 6 people, 21.43%
Stress And Anxiety: 3 people, 10.71%
Nausea And Vomiting: 3 people, 10.71%
Sleep Disorder: 2 people, 7.14%
Renal Cell Carcinoma (a kidney cancer): 2 people, 7.14%
Post-Traumatic Stress Disorder: 2 people, 7.14%
Nausea (feeling of having an urge to vomit): 2 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.14%
Depression: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Prinzide and Roxicodone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously