Prinzide and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prinzide (hydrochlorothiazide; lisinopril) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include insomnia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Prinzide and Spiriva. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

23 people who take Prinzide and Spiriva together, and have interactions are studied.

What are the common drug interactions of Prinzide and Spiriva, by gender? *:

female:

Insomnia (sleeplessness)
Intentional self-injury
Joint swelling
Mania (a state of abnormally elevated or irritable mood)
Nasal discomfort
Oropharyngeal pain
Pain in extremity
Pancreatic carcinoma (pancreatic cancer)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral ischaemia (impaired circulation to an extremity)

male:

Anaemia (lack of blood)
Aortic valve incompetence
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Compression fracture (fracture due to pressure caused by injury)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Ejection fraction decreased (systolic heart failure)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)

What are the common drug interactions of Prinzide and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Peripheral ischaemia (impaired circulation to an extremity)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
White blood cell count increased
Beta-2 glycoprotein antibody positive
Haematocrit decreased
Haemoglobin decreased
Platelet count increased
Antiphospholipid antibodies positive
Oedema peripheral (superficial swelling)
Pain in extremity

50-59:

Chronic kidney disease
Dry eye (lack of adequate tears)
Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
Fungal infection
Hypersensitivity
Joint swelling
Oedema peripheral (superficial swelling)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Swelling face
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Gingival swelling (gums swelling)
Anaemia (lack of blood)
Blood urea decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Compression fracture (fracture due to pressure caused by injury)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Ejection fraction decreased (systolic heart failure)

What are the existing conditions these people have? *

Pain: 5 people, 21.74%
High Blood Cholesterol: 4 people, 17.39%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 13.04%
Asthma: 3 people, 13.04%
Nausea (feeling of having an urge to vomit): 2 people, 8.70%
Hypersensitivity: 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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