Pristiq and Maxalt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pristiq (desvenlafaxine succinate) and Maxalt (rizatriptan benzoate). Common drug interactions include muscle twitching among females and abnormal sensation in eye among males.

The phase IV clinical study analyzes what interactions people have when they take Pristiq and Maxalt. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

On Jul, 09, 2026

39 people who take Pristiq and Maxalt together, and have interactions are studied.

What are the common drug interactions of Pristiq and Maxalt, by gender? *:

female:

Muscle twitching
Headache (pain in head)
Cholecystitis (infection of gallbladder)
Dizziness
Vomiting
Contusion (a type of hematoma of tissue in which capillaries)
Emotional disorder
Feeling cold
Herpes simplex serology positive
Hypercoagulation (increased tendency for clotting of the blood)

male:

Abnormal sensation in eye
Balance disorder
Disturbance in attention
Dizziness
Headache (pain in head)
Heart rate increased
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)
Vomiting

What are the common drug interactions of Pristiq and Maxalt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholecystitis (infection of gallbladder)

20-29:

Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Basal ganglia infarction (disruption of the blood flow in the small blood vessels in the white matter of the cerebral cortex)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dizziness
Hemiparesis (weakness on one side of the body)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Oedema peripheral (superficial swelling)
Pain
Swelling face

30-39:

Feeling cold
Aura
Dizziness
Feeling drunk
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Restlessness (not able to rest)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Chest discomfort

40-49:

Headache (pain in head)
Heart rate increased
Nausea (feeling of having an urge to vomit)
Dizziness
Drug effect decreased
Pancreatitis acute (sudden inflammation of pancreas)
Vomiting
Abnormal sensation in eye
Alanine aminotransferase increased
Aspartate aminotransferase increased

50-59:

Insomnia (sleeplessness)
Visual acuity reduced (reduced clearness of vision)
Alopecia (absence of hair from areas of the body)

60+:

Chest pain
Diarrhoea
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Pericarditis (inflammation of the pericardium)
Rash pruritic (redness with itching)
Rosacea (a skin condition that causes facial redness)
Skin exfoliation (removal of the oldest dead skin cells)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Vomiting

What are the existing conditions these people have? *

Premenstrual Syndrome: 5 people, 12.82%
Pain: 5 people, 12.82%
Stress And Anxiety: 3 people, 7.69%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.13%
Osteoporosis (bones weak and more likely to break): 2 people, 5.13%
Menstruation Irregular: 2 people, 5.13%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 5.13%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.13%
Dysmenorrhea (painful menstruation): 2 people, 5.13%
Birth Control: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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