Pristiq and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pristiq (desvenlafaxine succinate) and Reglan (metoclopramide hydrochloride). Common drug interactions include hypoaesthesia among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Pristiq and Reglan. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

55 people who take Pristiq and Reglan together, and have interactions are studied.

What are the common drug interactions of Pristiq and Reglan, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Impaired gastric emptying
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Intervertebral disc space narrowing (spinal disc space narrowing)
Laceration (tearing of soft body tissue)
Lung neoplasm malignant (cancer tumour of lung)
Lymphadenopathy (disease or enlargement of lymph nodes)

male:

Fall
Chest pain
Dizziness
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Emotional distress
Erectile dysfunction
Flushing (the warm, red condition of human skin)
Gastric disorder (disease of stomach)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Pristiq and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Insomnia (sleeplessness)
Feeling jittery
Myalgia (muscle pain)
Throat tightness
Vomiting

40-49:

Dystonia (abnormal muscle tone)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Diarrhoea
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Influenza
Pyrexia (fever)
Asthenia (weakness)
Burning sensation
Decreased appetite

50-59:

Rectal haemorrhage (bleeding from anus)
Respiratory failure (inadequate gas exchange by the respiratory system)
Restless legs syndrome (a powerful urge to move your legs)
Rhinorrhoea (watery mucus discharge from the nose)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Scrotal cyst (cyst of scrotum)
Second primary malignancy (after getting cure a cancer, a new cancer development)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Sinusitis (inflammation of sinus)

60+:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Arthralgia (joint pain)
Flatulence (flatus expelled through the anus)
Gait disturbance
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypotension (abnormally low blood pressure)
Oedema peripheral (superficial swelling)
Pain

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 16.36%
Gastric Disorder (disease of stomach): 9 people, 16.36%
Stress And Anxiety: 7 people, 12.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.73%
Diabetes: 6 people, 10.91%
Pain: 5 people, 9.09%
High Blood Pressure: 5 people, 9.09%
Headache (pain in head): 5 people, 9.09%
Quit Smoking: 4 people, 7.27%
Migraine (headache): 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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