Probenecid and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Probenecid (probenecid) and Protonix (pantoprazole sodium). Common drug interactions include renal tubular necrosis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Probenecid and Protonix. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 18, 2026

11 people who take Probenecid and Protonix together, and have interactions are studied.

Probenecid and Protonix drug interactions.

What are the common drug interactions of Probenecid and Protonix, by gender? *:

female:

Renal tubular necrosis (death of kidney tubules)
Right ventricular hypertrophy (right ventricular enlargement)
Sepsis (a severe blood infection that can lead to organ failure and death)
Streptococcal infection
Tricuspid valve incompetence (inefficient heart valve)
Troponin increased
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
White blood cell count increased
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)

male:

Anxiety
Arrhythmia (irregular heartbeat)
Dyspepsia (indigestion)
Fluid overload (too much fluid in the blood)
Haematocrit decreased
Loss of consciousness
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Pain

What are the common drug interactions of Probenecid and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

White blood cell count increased
Anaemia (lack of blood)
Anxiety
Bicuspid aortic valve
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chronic kidney disease
Coarctation of the aorta (narrowing of the part of aorta)
Depression
Injury
Maternal exposure during pregnancy (use of substance during pregnancy)

60+:

Pneumonia
Renal failure (kidney dysfunction)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspepsia (indigestion)
Fluid overload (too much fluid in the blood)
Haematocrit decreased
Loss of consciousness
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Depression: 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
Stress And Anxiety: 2 people, 18.18%
Diabetes: 1 person, 9.09%
Diabetes Mellitus Inadequate Control: 1 person, 9.09%
Diastolic Dysfunction: 1 person, 9.09%
Gastric Ph Decreased: 1 person, 9.09%
High Blood Cholesterol: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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