Prograf and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prograf (tacrolimus) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include accidental exposure among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Prograf and Avalide. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

On Aug, 03, 2026

11 people who take Prograf and Avalide together, and have interactions are studied.

What are the common drug interactions of Prograf and Avalide, by gender? *:

female:

Accidental exposure
Heart rate increased
Injection site anaesthesia
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site pallor (an unhealthy pale appearance at injection site)
Palpitations (feelings or sensations that your heart is pounding or racing)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Scar
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Abasia (inability to walk)
Arthralgia (joint pain)
Balance disorder

What are the common drug interactions of Prograf and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Abasia (inability to walk)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Balance disorder
Burning sensation
Dry skin
Dyspnoea (difficult or laboured respiration)
Emotional distress

50-59:

Injury
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

60+:

Oedema peripheral (superficial swelling)
Renal disorder (kidney disease)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Abdominal: 3 people, 27.27%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 18.18%
Diabetes: 2 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
High Blood Cholesterol: 2 people, 18.18%
Anaemia (lack of blood): 2 people, 18.18%
Pain: 2 people, 18.18%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 18.18%
Nuclear Magnetic Resonance Imaging Brain: 1 person, 9.09%
Osteoporosis (bones weak and more likely to break): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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