Prograf and Zyvox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prograf (tacrolimus) and Zyvox (linezolid). Common drug interactions include oedema peripheral among females and skin ulcer among males.

The phase IV clinical study analyzes what interactions people have when they take Prograf and Zyvox. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

What is Zyvox?

Zyvox has active ingredients of linezolid. It is often used in mrsa infection. eHealthMe is studying from 9,399 Zyvox users. Check the latest studies of Zyvox.

On Jul, 24, 2026

74 people who take Prograf and Zyvox together, and have interactions are studied.

What are the common drug interactions of Prograf and Zyvox, by gender? *:

female:

Oedema peripheral (superficial swelling)
Platelet count decreased
Abdominal pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Back pain
Bacteraemia (presence of bacteria in the blood)
Blood testosterone decreased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis (inflammation of colon)
Conjunctival disorder (conjunctival disease)

male:

Skin ulcer
Pneumonia
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
International normalised ratio increased
Localised infection (infection at the single location)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Post procedural haemorrhage (post procedural bleeding)
Cytomegalovirus infection
Erythema (redness of the skin)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Prograf and Zyvox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection bacterial
Depressed level of consciousness
Abdominal pain
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Altered state of consciousness (altered state of mind)
Cardiac arrest
Catheter site erythema (redness of skin at catheter site)
Catheter site swelling

10-19:

Blood bilirubin increased
Blood glucose increased
Fungal infection
Fusarium infection (fungal infection)
Platelet count decreased
White blood cell count decreased
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood creatinine increased

20-29:

Hepatic failure (liver failure)
Lung infection pseudomonal (bacterial infection of lung by pseudomonas aeruginosa)
Renal failure acute (rapid kidney dysfunction)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Lactic acidosis (low ph in body tissues)
Renal impairment (severely reduced kidney function)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone pain
Burning sensation
Deformity (disfigurement)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)

40-49:

Blood creatinine increased
Abscess (pus)
Exostosis (formation of new bone on the surface of a bone)
International normalised ratio increased
Localised infection (infection at the single location)
Muscular weakness (muscle weakness)
Post procedural haemorrhage (post procedural bleeding)
Skin ulcer
Hepatic ischaemia (liver does not get enough blood or oxygen, causing injury to liver cells)
Pyrexia (fever)

50-59:

Abdominal pain
Back pain
Colitis (inflammation of colon)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Bacteraemia (presence of bacteria in the blood)
Blood testosterone decreased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Conjunctival disorder (conjunctival disease)

60+:

Multi-organ failure (multisystem organ failure)
Renal failure (kidney dysfunction)
Cardiac failure
Altered state of consciousness (altered state of mind)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood creatine phosphokinase increased
Cardiac arrest

What are the existing conditions these people have? *

Pain: 8 people, 10.81%
Nausea (feeling of having an urge to vomit): 6 people, 8.11%
Infection: 6 people, 8.11%
Skin Ulcer: 5 people, 6.76%
Mouth Ulcers: 5 people, 6.76%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 6.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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