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Prolia and Endep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Endep (amitriptyline hydrochloride). Common drug interactions include urinary tract infection among females.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Endep. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

On Jul, 18, 2026

22 people who take Prolia and Endep together, and have interactions are studied.

Prolia and Endep drug interactions.

What are the common drug interactions of Prolia and Endep, by gender? *:

female:

  1. Urinary tract infection
  2. Fatigue (feeling of tiredness)
  3. Feeling hot
  4. Headache (pain in head)
  5. Impaired healing
  6. Influenza
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Pain in jaw
  9. Peripheral coldness
  10. Urinary incontinence (inability to control the flow of urine and involuntary urination)

male:

n/a

What are the common drug interactions of Prolia and Endep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Urinary tract infection
  2. Device dislocation
  3. Synovial cyst (cyst of joint filled with synovial fluid)
  4. Vulvovaginal candidiasis (vulvovaginal infection by fungi)
  5. Urinary incontinence (inability to control the flow of urine and involuntary urination)
  6. Herpes zoster
  7. Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
  8. Escherichia infection (bacterial infection by escherichia coli)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

  1. Fatigue (feeling of tiredness)
  2. Back pain
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Pain in jaw
  5. Peripheral coldness
  6. Vision blurred
  7. Adverse event
  8. Arrhythmia (irregular heartbeat)
  9. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  10. Decreased appetite

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 18.18%
  2. Stress And Anxiety: 3 people, 13.64%
  3. Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 13.64%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%
  5. High Blood Pressure: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and Endep?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prolia and Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prolia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Endep and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on denosumab and amitriptyline hydrochloride (the active ingredients of Prolia and Endep, respectively), and Prolia and Endep (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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