Prolia and Gravol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Gravol (dimenhydrinate). Common drug interactions include rheumatoid arthritis among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Gravol. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

What is Gravol?

Gravol has active ingredients of dimenhydrinate. It is often used in nausea. eHealthMe is studying from 7,193 Gravol users. Check the latest studies of Gravol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

45 people who take Prolia and Gravol together, and have interactions are studied.

What are the common drug interactions of Prolia and Gravol, by gender? *:

female:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Weight increased
Cough
Joint injury
Joint swelling
Productive cough
Hypotension (abnormally low blood pressure)
Arthropathy
Asthma
Blood pressure diastolic decreased

male:

Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Irritable bowel syndrome
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Prolia and Gravol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Balance disorder
Blood pressure fluctuation
Blood pressure increased
C-reactive protein increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dysstasia (difficulty in standing)
Feeding disorder (when children refuse to eat certain food groups)
Haematuria (presence of blood in urine)
Joint injury
Limb injury

40-49:

n/a

50-59:

Drug intolerance (drug sensitivity)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Haemorrhage (bleeding)
Hypotension (abnormally low blood pressure)
Joint injury
Joint swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Fatigue (feeling of tiredness)
Diarrhoea
Arthralgia (joint pain)
Intestinal obstruction
Stress
Anaemia (lack of blood)
Drug ineffective
Platelet count decreased
Dizziness
Blood urine present

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 21 people, 46.67%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 9 people, 20.00%
Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 8.89%
Microscopic Polyangiitis (inflammation involving multiple blood or lymph small-vessel): 4 people, 8.89%
Pain: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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