Prolia and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Macrobid. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

64 people who take Prolia and Macrobid together, and have interactions are studied.

What are the common drug interactions of Prolia and Macrobid, by gender? *:

female:

Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Fungal infection
Injection site pain
Myalgia (muscle pain)
Sinusitis (inflammation of sinus)
White blood cell count decreased
Haemorrhage (bleeding)
Abdominal distension
Infusion site extravasation (flow of (blood or lymph) from infusion site)

male:

n/a

What are the common drug interactions of Prolia and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Femur fracture

40-49:

Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fall
Headache (pain in head)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Nausea (feeling of having an urge to vomit)
Pain in jaw
Post procedural complication
Tinnitus (a ringing in the ears)

50-59:

Abdominal pain
Adverse drug reaction
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Throat irritation
Atrophic vulvovaginitis (inflammation of the vulva)
Bone density decreased
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

60+:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Abdominal distension
Blood pressure increased
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Fungal infection
Headache (pain in head)
Alopecia (absence of hair from areas of the body)
Ear infection

What are the existing conditions these people have? *

Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 17 people, 26.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 10.94%
Immunodeficiency Common Variable: 7 people, 10.94%
High Blood Cholesterol: 6 people, 9.38%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 9.38%
Respiratory Tract Infection Viral: 5 people, 7.81%
Respiratory Tract Infection Bacterial: 5 people, 7.81%
Insomnia (sleeplessness): 5 people, 7.81%
Blood Pressure Abnormal: 5 people, 7.81%
Asthma: 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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