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Prolia and Ursodeoxycholic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prolia (denosumab) and Ursodeoxycholic acid (ursodiol). Common drug interactions include pruritus among females.

The phase IV clinical study analyzes what interactions people have when they take Prolia and Ursodeoxycholic acid. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

What is Ursodeoxycholic acid?

Ursodeoxycholic acid has active ingredients of ursodiol. It is often used in biliary cirrhosis primary. eHealthMe is studying from 7,528 Ursodeoxycholic acid users. Check the latest studies of Ursodeoxycholic acid.

On Jul, 16, 2026

15 people who take Prolia and Ursodeoxycholic acid together, and have interactions are studied.

Prolia and Ursodeoxycholic acid drug interactions.

What are the common drug interactions of Prolia and Ursodeoxycholic Acid, by gender? *:

female:

  1. Pruritus (severe itching of the skin)
  2. Erythema (redness of the skin)
  3. Aspartate aminotransferase increased
  4. Chest pain
  5. Follicle centre lymphoma, follicular grade i, ii, iii recurrent
  6. Pneumonia
  7. Vertigo
  8. Abasia (inability to walk)
  9. Arrhythmia (irregular heartbeat)
  10. Back pain

male:

n/a

What are the common drug interactions of Prolia and Ursodeoxycholic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Dizziness
  2. Injection site pain
  3. Migraine (headache)
  4. Nausea (feeling of having an urge to vomit)
  5. Vertigo

60+:

  1. Pruritus (severe itching of the skin)
  2. Erythema (redness of the skin)
  3. Arrhythmia (irregular heartbeat)
  4. Back pain
  5. Bone disorder
  6. Bruxism (habitual grinding of the teeth, typically during sleep)
  7. Cardiac failure
  8. Deafness
  9. Dental caries
  10. Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

  1. Glossitis (infection of tongue with soreness): 5 people, 33.33%
  2. Hyperkalemia (damage to or disease of the kidney): 2 people, 13.33%
  3. Type 2 Diabetes: 1 person, 6.67%
  4. Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 6.67%
  5. Neck Pain: 1 person, 6.67%
  6. Migraine (headache): 1 person, 6.67%
  7. High Blood Pressure: 1 person, 6.67%
  8. High Blood Cholesterol: 1 person, 6.67%
  9. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 6.67%
  10. Follicle Centre Lymphoma, Follicular Grade I, Ii, Iii: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and Ursodeoxycholic acid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prolia and Ursodeoxycholic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ursodeoxycholic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prolia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ursodeoxycholic acid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on denosumab and ursodiol (the active ingredients of Prolia and Ursodeoxycholic acid, respectively), and Prolia and Ursodeoxycholic acid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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