Promethazine dm and Loraz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine dm (dextromethorphan hydrobromide; promethazine hydrochloride) and Loraz (lorazepam). Common drug interactions include diarrhoea among females and pancreatitis among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine dm and Loraz. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine dm?

Promethazine dm has active ingredients of dextromethorphan hydrobromide; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 624 Promethazine dm users. Check the latest studies of Promethazine dm.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,694 Loraz users. Check the latest studies of Loraz.

On Jul, 09, 2026

35 people who take Promethazine dm and Loraz together, and have interactions are studied.

Promethazine dm and Loraz drug interactions.

What are the common drug interactions of Promethazine Dm and Loraz, by gender? *:

female:

Diarrhoea
Abdominal pain
Influenza
Blood pressure increased
Chest pain
Dizziness
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)

male:

Pancreatitis (inflammation of pancreas)
Bladder dilatation
Arthralgia (joint pain)
Bone density decreased
Bone loss
Constipation
Death
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Emotional distress

What are the common drug interactions of Promethazine Dm and Loraz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death

40-49:

Abdominal pain
Blood pressure increased
Chest pain
Diarrhoea
Dizziness
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Impaired gastric emptying
Influenza
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective

50-59:

Pancreatitis (inflammation of pancreas)
Bladder dilatation
Blood sodium decreased
Urinary tract infection
Decreased appetite
Lethargy (tiredness)
Unresponsive to stimuli
Weight decreased
Arthralgia (joint pain)
Drug ineffective

60+:

Constipation
Diarrhoea
Vomiting
Abdominal pain
Arthropathy
Dyspnoea (difficult or laboured respiration)
Epigastric discomfort
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Headache (pain in head)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 25.71%
Hypersensitivity: 6 people, 17.14%
Pain: 6 people, 17.14%
Nausea (feeling of having an urge to vomit): 6 people, 17.14%
High Blood Pressure: 5 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.29%
Constipation: 5 people, 14.29%
Migraine (headache): 5 people, 14.29%
Depression: 5 people, 14.29%
Diarrhea: 4 people, 11.43%

* Approximation only. Some reports may have incomplete information.

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