Promethazine w/ codeine and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine w/ codeine (codeine phosphate; promethazine hydrochloride) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include anxiety among females and actinomycosis among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine w/ codeine and Spiriva. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine w/ codeine?

Promethazine w/ codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 279 Promethazine w/ codeine users. Check the latest studies of Promethazine w/ codeine.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

On Jul, 07, 2026

14 people who take Promethazine w/ codeine and Spiriva together, and have interactions are studied.

Promethazine w/ codeine and Spiriva drug interactions.

What are the common drug interactions of Promethazine W/ Codeine and Spiriva, by gender? *:

female:

Anxiety
Bipolar disorder (mood disorder)
Depression
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Mood swings (an extreme or rapid change in mood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Suicide attempt

male:

Actinomycosis (infection that causes sores, or abscesses)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Cataract (clouding of the lens inside the eye)
Cerebral atrophy (decrement in size of brain)
Decreased activity
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Disease progression
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Promethazine W/ Codeine and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Actinomycosis (infection that causes sores, or abscesses)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Arthralgia (joint pain)
Back pain
Balance disorder
Blood creatinine increased
Bone disorder
Breath odour
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest

60+:

Influenza
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Thrombosis (formation of a blood clot inside a blood vessel)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pneumonia
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Pain: 12 people, 85.71%
Metastases To Bone (cancer spreads to bone): 9 people, 64.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
Asthma: 3 people, 21.43%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 2 people, 14.29%
Hypersensitivity: 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%
High Blood Cholesterol: 1 person, 7.14%
Quit Smoking: 1 person, 7.14%
Fungal Infection: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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