Promethazine with codeine and Losartan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine with codeine (codeine phosphate; promethazine hydrochloride) and Losartan (losartan potassium). Common drug interactions include chronic kidney disease among females and aphonia among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine with codeine and Losartan. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine with codeine?

Promethazine with codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 269 Promethazine with codeine users. Check the latest studies of Promethazine with codeine.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,695 Losartan users. Check the latest studies of Losartan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Promethazine with codeine and Losartan together, and have interactions are studied.

Promethazine with codeine and Losartan drug interactions.

What are the common drug interactions of Promethazine With Codeine and Losartan, by gender? *:

female:

Chronic kidney disease
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Poor quality sleep
Retinal toxicity (retina damage due to medication)
Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Death

male:

Aphonia (inability to produce voice)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Nausea (feeling of having an urge to vomit)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Pneumonia fungal
Productive cough
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fall

What are the common drug interactions of Promethazine With Codeine and Losartan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Retinal toxicity (retina damage due to medication)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)

50-59:

Chronic kidney disease
Death

60+:

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dyspnoea (difficult or laboured respiration)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fall
Fear
Hip fracture
Nausea (feeling of having an urge to vomit)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)

What are the existing conditions these people have? *

Infection: 6 people, 40.00%
Pain: 5 people, 33.33%
High Blood Cholesterol: 5 people, 33.33%
Depression: 5 people, 33.33%
Nausea (feeling of having an urge to vomit): 4 people, 26.67%
Asthma: 4 people, 26.67%
Constipation: 4 people, 26.67%
Inflammation: 4 people, 26.67%
Hypersensitivity: 4 people, 26.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 26.67%

* Approximation only. Some reports may have incomplete information.

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