Promethazine with codeine and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine with codeine (codeine phosphate; promethazine hydrochloride) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include fatigue among females and abdominal pain lower among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine with codeine and Spiriva. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine with codeine?

Promethazine with codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 269 Promethazine with codeine users. Check the latest studies of Promethazine with codeine.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

On Jul, 13, 2026

14 people who take Promethazine with codeine and Spiriva together, and have interactions are studied.

Promethazine with codeine and Spiriva drug interactions.

What are the common drug interactions of Promethazine With Codeine and Spiriva, by gender? *:

female:

Fatigue (feeling of tiredness)
Chest pain
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Urticaria (rash of round, red welts on the skin that itch intensely)
Asthenia (weakness)
Diarrhoea
Dyspepsia (indigestion)
Heart rate increased
Poor quality sleep

male:

Abdominal pain lower
Benign prostatic hyperplasia (benign enlargement of the prostate)
Rash pruritic (redness with itching)
Skin irritation
Urinary tract infection
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pneumonia
Cystitis (inflammation of the wall of the bladder)
Erythema (redness of the skin)
Infection

What are the common drug interactions of Promethazine With Codeine and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest pain
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Productive cough
Abdominal pain
Abdominal pain upper
Acute respiratory failure
Asthenia (weakness)
Cardiac failure congestive
Chills (felling of cold)

50-59:

Oedema (fluid collection in tissue)
Urinary tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain lower
Benign prostatic hyperplasia (benign enlargement of the prostate)
Cystitis (inflammation of the wall of the bladder)
Erythema (redness of the skin)
Infection
Infusion site rash
Injection site erythema (redness at injection site)

60+:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Throat irritation
Upper-airway cough syndrome
Diarrhoea
Drug effect decreased
Fatigue (feeling of tiredness)
Hypersensitivity
Inner ear inflammation
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Asthma: 6 people, 42.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 42.86%
Hypersensitivity: 5 people, 35.71%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 28.57%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 21.43%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 21.43%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 21.43%
Diabetes: 3 people, 21.43%
Constipation: 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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