Promethazine and Acephen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Acephen (acetaminophen). Common drug interactions include conjunctivitis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Acephen. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Acephen?

Acephen has active ingredients of acetaminophen. eHealthMe is studying from 91 Acephen users. Check the latest studies of Acephen.

On Feb, 10, 2026

22 people who take Promethazine and Acephen together, and have interactions are studied.

Promethazine and Acephen drug interactions.

What are the common drug interactions of Promethazine and Acephen, by gender? *:

female:

Conjunctivitis (pink eye)
Hypersensitivity
Orbital oedema (swelling of orbit)
Pneumomediastinum (air is present in the mediastinum)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Sepsis (a severe blood infection that can lead to organ failure and death)
Subcutaneous emphysema (smooth bulging of the skin)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fatigue (feeling of tiredness)
Oesophageal infection
Alcoholic seizure

What are the common drug interactions of Promethazine and Acephen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)
Bone metabolism disorder
Alcoholic seizure
Bone disorder

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Oesophageal infection
Colorectal cancer stage ii (cancer has grown into the outermost layers of the colon or rectum to near organ)
Gastric cancer (stomach cancer)
Laryngeal cancer (cancer of the larynx)
Signet-ring cell carcinoma (signet cell cancer tumour)
Renal injury (kidney injury)
Bladder cancer
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

What are the existing conditions these people have? *

Hiv Infection: 11 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 36.36%
Pain: 2 people, 9.09%
Infection: 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
Gastritis (inflammation of stomach): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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