Promethazine and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Atarax (hydroxyzine hydrochloride). Common drug interactions include urinary tract infection among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Atarax. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

90 people who take Promethazine and Atarax together, and have interactions are studied.

Promethazine and Atarax drug interactions.

What are the common drug interactions of Promethazine and Atarax, by gender? *:

female:

Urinary tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight decreased
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Anaemia (lack of blood)
Aortic calcification (aortic calcification sign of heart valve disease)
Arthralgia (joint pain)
Asthma
Atelectasis (partial or complete collapse of the lung)

male:

Asthenia (weakness)
Chronic kidney disease
Confusional state
Emotional distress
Intentional self-injury
Osteopenia (a condition where bone mineral density is lower than normal)
Neuralgia (pain in one or more nerves)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Promethazine and Atarax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Upper respiratory tract infection

20-29:

Arthralgia (joint pain)
Headache (pain in head)
Dysgeusia (disorder of the sense of taste)
Emotional distress
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Pain
Sleep disorder
Ulcer
Adverse reaction

30-39:

Influenza like illness
Asthenia (weakness)
Diarrhoea
Fatigue (feeling of tiredness)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Chest pain
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Suicide attempt

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Acute hepatic failure
Acute respiratory failure
Drug administration error
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
Overdose
Asthenia (weakness)
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)

50-59:

Cough
Gait disturbance
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Pyrexia (fever)
Renal impairment (severely reduced kidney function)
Neuralgia (pain in one or more nerves)
Abdominal discomfort

60+:

Rash
Asthenia (weakness)
Pain in extremity
Renal failure (kidney dysfunction)
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aortic calcification (aortic calcification sign of heart valve disease)
Asthma

What are the existing conditions these people have? *

Pain: 20 people, 22.22%
Itching: 19 people, 21.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 20.00%
Nausea And Vomiting: 10 people, 11.11%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 9 people, 10.00%
High Blood Cholesterol: 9 people, 10.00%
Insomnia (sleeplessness): 9 people, 10.00%
Asthma: 8 people, 8.89%
High Blood Pressure: 8 people, 8.89%
Depression: 7 people, 7.78%

* Approximation only. Some reports may have incomplete information.

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