Promethazine and Desloratadine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Desloratadine (desloratadine). Common drug interactions include cough among females and dermatitis among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Desloratadine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Desloratadine?

Desloratadine has active ingredients of desloratadine. It is often used in allergies. eHealthMe is studying from 4,207 Desloratadine users. Check the latest studies of Desloratadine.

On Jul, 13, 2026

28 people who take Promethazine and Desloratadine together, and have interactions are studied.

Promethazine and Desloratadine drug interactions.

What are the common drug interactions of Promethazine and Desloratadine, by gender? *:

female:

Cough
Arthralgia (joint pain)
Dementia (madness)
Pain
Alopecia (absence of hair from areas of the body)
Back pain
Cholecystitis (infection of gallbladder)
Chronic kidney disease
Drug ineffective
Dyspnoea (difficult or laboured respiration)

male:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Decreased appetite
Epicondylitis (tennis elbow)
Feeling hot
Gallbladder disorder
Local swelling (swelling at the site of some application of substance or injury)
Pneumonia

What are the common drug interactions of Promethazine and Desloratadine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholecystitis (infection of gallbladder)
Decreased appetite

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis (infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Oedema (fluid collection in tissue)

40-49:

n/a

50-59:

Chronic kidney disease
Abortion spontaneous (naturally occurring miscarriage)
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aphasia (damage to the parts of the brain that control language)
Chills (felling of cold)
Communication disorder (speech and language disorder)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Diarrhoea

60+:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Age-related macular degeneration
Decreased appetite
Immobile (not moving)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Pneumonia

What are the existing conditions these people have? *

Asthma: 5 people, 17.86%
Thrombocytopenia (decrease of platelets in blood): 5 people, 17.86%
Stress And Anxiety: 4 people, 14.29%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 14.29%
High Blood Pressure: 4 people, 14.29%
Hypersensitivity: 4 people, 14.29%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 14.29%
Migraine (headache): 4 people, 14.29%
White Blood Cell Count Decreased: 3 people, 10.71%
Multiple Allergies (allergy to multiple agents): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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