Promethazine and Esgic-plus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Esgic-plus (acetaminophen; butalbital; caffeine). Common drug interactions include sinusitis among females.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Esgic-plus. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Esgic-plus?

Esgic-plus has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 269 Esgic-plus users. Check the latest studies of Esgic-plus.

On Jul, 04, 2026

18 people who take Promethazine and Esgic-plus together, and have interactions are studied.

Promethazine and Esgic-plus drug interactions.

What are the common drug interactions of Promethazine and Esgic-Plus, by gender? *:

female:

Sinusitis (inflammation of sinus)
Malaise (a feeling of general discomfort or uneasiness)
Diarrhoea
Diplopia (double vision)
Ear infection
Eyelid ptosis (falling of the upper or lower eyelid)
Food poisoning (poison in food)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemorrhage (bleeding)

male:

n/a

What are the common drug interactions of Promethazine and Esgic-Plus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Adjustment disorder with depressed mood
Aphonia (inability to produce voice)
Contusion (a type of hematoma of tissue in which capillaries)
Ear infection
Haemorrhage (bleeding)
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nasopharyngitis (inflammation of the nasopharynx)
Post-traumatic stress disorder

50-59:

Agitation (state of anxiety or nervous excitement)
Bladder neck suspension
Neuromyopathy (disease of both muscles and nerves)
Osteoporosis (bones weak and more likely to break)
Otitis media (inflammation of the middle ear)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sinusitis (inflammation of sinus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Visual impairment
Bradycardia (abnormally slow heart action)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 77.78%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 77.78%
Sleep Disorder: 4 people, 22.22%

* Approximation only. Some reports may have incomplete information.

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