Promethazine and Etoposide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Etoposide (etoposide). Common drug interactions include neutrophil count decreased among females and dystonia among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Etoposide. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Etoposide?

Etoposide has active ingredients of etoposide. eHealthMe is studying from 77,815 Etoposide users. Check the latest studies of Etoposide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

97 people who take Promethazine and Etoposide together, and have interactions are studied.

Promethazine and Etoposide drug interactions.

What are the common drug interactions of Promethazine and Etoposide, by gender? *:

female:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Chest pain
Death
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Pyrexia (fever)
Aphasia (damage to the parts of the brain that control language)
Dysarthria (speech disorder)
Headache (pain in head)
Medulloblastoma recurrent (reoccurrence of a fast-growing, high-grade tumour that always begins in the cerebellum)

male:

Dystonia (abnormal muscle tone)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
White blood cell count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Peripheral swelling
Feeding disorder (when children refuse to eat certain food groups)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Myelosuppression (a decrease in the production of blood cells)
Platelet count decreased
Urinary tract infection

What are the common drug interactions of Promethazine and Etoposide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dystonia (abnormal muscle tone)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Electrolyte imbalance
Dehydration (dryness resulting from the removal of water)
Colitis (inflammation of colon)
Eating disorder
Mucosal inflammation (infection of mucous membrane)
Feeding disorder (when children refuse to eat certain food groups)
Bacteraemia (presence of bacteria in the blood)

10-19:

Aphasia (damage to the parts of the brain that control language)
Dysarthria (speech disorder)
Headache (pain in head)
Medulloblastoma recurrent (reoccurrence of a fast-growing, high-grade tumour that always begins in the cerebellum)
Pyrexia (fever)
Dysphagia (a condition in which swallowing is difficult or painful)

20-29:

Cytomegalovirus infection
Fibula fracture
Greenstick fracture (soft bone in which the bone bends and partially breaks)
Histiocytosis haematophagic
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

30-39:

Drug hypersensitivity
Lip swelling
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Skin reaction
Swollen tongue (swelling of tongue)
Throat tightness

40-49:

Lung abscess (pus in lungs)
Bacterial sepsis
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Drug ineffective
Febrile neutropenia (fever with reduced white blood cells)
Neutropenia (an abnormally low number of neutrophils)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Pyrexia (fever)
Refractory cancer (cancer that has not responded to treatment)
Richter's syndrome (hairy cell cancer changes in fast growing b cell cancer tumour)

50-59:

Platelet count decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Death
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Back pain
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Febrile neutropenia (fever with reduced white blood cells)

60+:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Pruritus (severe itching of the skin)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Death
White blood cell count decreased
Peripheral swelling
Anaemia (lack of blood)
Myelosuppression (a decrease in the production of blood cells)
Pneumonia
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 36 people, 37.11%
Pain: 14 people, 14.43%
Nausea And Vomiting: 10 people, 10.31%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 8 people, 8.25%
Constipation: 8 people, 8.25%
Tumor: 7 people, 7.22%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 7 people, 7.22%
Lung Cancer - Small Cell (lung cancer): 6 people, 6.19%
Insomnia (sleeplessness): 6 people, 6.19%
Thrombocytopenia (decrease of platelets in blood): 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine and Etoposide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously