Promethazine and Gleevec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Gleevec (imatinib mesylate). Common drug interactions include oedema among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Gleevec. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Gleevec?

Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

31 people who take Promethazine and Gleevec together, and have interactions are studied.

Promethazine and Gleevec drug interactions.

What are the common drug interactions of Promethazine and Gleevec, by gender? *:

female:

Oedema (fluid collection in tissue)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pulmonary oedema (fluid accumulation in the lungs)
Renal failure (kidney dysfunction)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Suicidal ideation
Vitamin b12 decreased

male:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dyspnoea (difficult or laboured respiration)
Death
Drug ineffective
Dry mouth
Emotional disorder
Eye pain
Fall
Foot fracture
Gait disturbance

What are the common drug interactions of Promethazine and Gleevec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cytomegalovirus gastritis (virus infection of stomach)
Malaise (a feeling of general discomfort or uneasiness)
Neoplasm malignant (cancer tumour)

40-49:

Cardiac failure congestive
Death
Dry mouth
Fall
Gastric cancer (stomach cancer)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Influenza
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuropathy peripheral (surface nerve damage)
Pneumonia
Abdominal pain upper
Arthralgia (joint pain)
Constipation
Crying
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)
Anaemia (lack of blood)
Eye swelling
Fatigue (feeling of tiredness)
Haematocrit decreased
Haemoglobin decreased
Intra-abdominal pressure increased
Joint swelling
Lymphocyte count decreased
Pain

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 8 people, 25.81%
Gastrointestinal Stromal Tumor: 6 people, 19.35%
Pain: 3 people, 9.68%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 9.68%
Stress And Anxiety: 2 people, 6.45%
Osteoporosis (bones weak and more likely to break): 2 people, 6.45%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.45%
Headache (pain in head): 2 people, 6.45%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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