1. Home
  2. Analysis
  3. Promethazine
  4. Invokamet

Promethazine and Invokamet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Invokamet (canagliflozin; metformin hydrochloride). Common drug interactions include pain among females.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Invokamet. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Invokamet?

Invokamet has active ingredients of canagliflozin; metformin hydrochloride. eHealthMe is studying from 1,965 Invokamet users. Check the latest studies of Invokamet.

On Jul, 11, 2026

18 people who take Promethazine and Invokamet together, and have interactions are studied.

Promethazine and Invokamet drug interactions.

What are the common drug interactions of Promethazine and Invokamet, by gender? *:

female:

  1. Pain
  2. Nephrolithiasis (calculi in the kidneys)
  3. Hysterectomy
  4. Spinal fusion surgery
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Anxiety
  7. Asthenia (weakness)
  8. Asthma
  9. Bone density decreased
  10. Bone disorder

male:

n/a

What are the common drug interactions of Promethazine and Invokamet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Cystitis (inflammation of the wall of the bladder)
  2. Hospitalisation
  3. Memory impairment
  4. Spinal fusion surgery
  5. Diplopia (double vision)
  6. Pain
  7. Poor quality sleep
  8. Retinal vascular disorder (a range of eye diseases that affect the blood vessels in the eye)
  9. Asthma
  10. Diarrhoea

50-59:

  1. Foot fracture
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Multiple fractures
  4. Osteopenia (a condition where bone mineral density is lower than normal)
  5. Osteoporosis (bones weak and more likely to break)
  6. Pain
  7. Anxiety
  8. Asthenia (weakness)
  9. Bone density decreased
  10. Bone disorder

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 83.33%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 55.56%
  3. Drowsiness: 2 people, 11.11%
  4. Weight Loss: 1 person, 5.56%
  5. Type 2 Diabetes: 1 person, 5.56%
  6. Pain: 1 person, 5.56%
  7. Migraine (headache): 1 person, 5.56%
  8. Hiv Infection: 1 person, 5.56%
  9. Diabetes: 1 person, 5.56%
  10. Breast Cancer Female: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine and Invokamet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Promethazine and Invokamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Promethazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Invokamet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Promethazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Invokamet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on promethazine hydrochloride and canagliflozin; metformin hydrochloride (the active ingredients of Promethazine and Invokamet, respectively), and Promethazine and Invokamet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.