Promethazine and Lonox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Lonox (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include dehydration among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Lonox. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Lonox?

Lonox has active ingredients of atropine sulfate; diphenoxylate hydrochloride. eHealthMe is studying from 376 Lonox users. Check the latest studies of Lonox.

On Jul, 18, 2026

13 people who take Promethazine and Lonox together, and have interactions are studied.

Promethazine and Lonox drug interactions.

What are the common drug interactions of Promethazine and Lonox, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Dizziness
Mucosal inflammation (infection of mucous membrane)
Palpitations (feelings or sensations that your heart is pounding or racing)
Vision blurred
Agitation (state of anxiety or nervous excitement)
Anxiety
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatine increased

male:

Chronic kidney disease
Anxiety
Death

What are the common drug interactions of Promethazine and Lonox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Rash
Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Mucosal inflammation (infection of mucous membrane)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Fatigue (feeling of tiredness)
Haematoma (collection of blood outside the blood vessels)
Haemorrhage (bleeding)
Hypersensitivity

60+:

Chronic kidney disease
Anxiety
Death
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dry mouth
Fatigue (feeling of tiredness)
Feeling of body temperature change
Fungal infection
Heart rate decreased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 53.85%
Pain: 6 people, 46.15%
Muscle Spasms (muscle contraction): 4 people, 30.77%
High Blood Pressure: 4 people, 30.77%
High Blood Cholesterol: 3 people, 23.08%
Neuralgia (pain in one or more nerves): 3 people, 23.08%
Multiple Allergies (allergy to multiple agents): 3 people, 23.08%
Infection: 3 people, 23.08%
Stress And Anxiety: 3 people, 23.08%
Chest Pain: 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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