Promethazine and Marijuana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Marijuana (marijuana). Common drug interactions include bone lesion among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Marijuana. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Marijuana?

Marijuana has active ingredients of marijuana. It is often used in stress and anxiety. eHealthMe is studying from 7,397 Marijuana users. Check the latest studies of Marijuana.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

63 people who take Promethazine and Marijuana together, and have interactions are studied.

Promethazine and Marijuana drug interactions.

What are the common drug interactions of Promethazine and Marijuana, by gender? *:

female:

Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone swelling
Cardiac disorder
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cyst (a closed sac)
Decreased interest

male:

Death
Drug ineffective
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Weight decreased
Constipation
Dysarthria (speech disorder)
Electric shock
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)

What are the common drug interactions of Promethazine and Marijuana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Impaired healing
General physical health deterioration (weak health status)
Cardiac arrest
Drug abuse
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Abscess jaw (tooth abscess or root abscess)
Ataxia (loss of full control of bodily movements)
Back pain

30-39:

Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Confusional state
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cyst (a closed sac)
Deafness
Decreased appetite
Decreased interest
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

40-49:

Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Burning sensation
Drug ineffective
Dysarthria (speech disorder)
Electric shock
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gait disturbance
Hemiparesis (weakness on one side of the body)

50-59:

Dry eye (lack of adequate tears)
Fatigue (feeling of tiredness)
Fungal infection
Headache (pain in head)
Insomnia (sleeplessness)
Nail disorder (disease of nail)
Nasopharyngitis (inflammation of the nasopharynx)
Onychoclasis (breaking of the nails)
Pain in extremity
Rash

60+:

Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)
Arthralgia (joint pain)
Dizziness
Fatigue (feeling of tiredness)
Hangover
Unresponsive to stimuli
Urinary tract infection

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 19.05%
Pain: 8 people, 12.70%
Muscle Spasms (muscle contraction): 6 people, 9.52%
Depression: 6 people, 9.52%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 5 people, 7.94%
Nausea And Vomiting: 4 people, 6.35%
Migraine (headache): 4 people, 6.35%
Hand Fracture: 4 people, 6.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.35%
Back Pain: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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