Promethazine and Nuplazid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Nuplazid (pimavanserin tartrate). Common drug interactions include renal failure among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Nuplazid. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

On Jul, 27, 2026

60 people who take Promethazine and Nuplazid together, and have interactions are studied.

Promethazine and Nuplazid drug interactions.

What are the common drug interactions of Promethazine and Nuplazid, by gender? *:

female:

Renal failure (kidney dysfunction)
Respiratory disorder (respiratory disease)
Swollen tongue (swelling of tongue)
Hallucination (an experience involving the perception of something not present)
Back pain
Delusion (a false belief or opinion)
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Therapeutic response unexpected

male:

Confusional state
Hallucination (an experience involving the perception of something not present)
Unresponsive to stimuli
Urinary tract infection bacterial
Fall
Muscular weakness (muscle weakness)
Oedema peripheral (superficial swelling)
Peripheral swelling
Tremor (trembling or shaking movements in one or more parts of your body)
Dysphagia (a condition in which swallowing is difficult or painful)

What are the common drug interactions of Promethazine and Nuplazid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Eye swelling
Somnolence (a state of near-sleep, a strong desire for sleep)
Nonspecific reaction (unspecified reaction)
Back pain
Blood glucose decreased
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Joint stiffness
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Dyspnoea (difficult or laboured respiration)
Heart rate increased
Nephrolithiasis (calculi in the kidneys)
Swelling

60+:

Hallucination (an experience involving the perception of something not present)
Death
Confusional state
Dizziness
Fatigue (feeling of tiredness)
Ill-defined disorder
Surgery
Diarrhoea
Rash pruritic (redness with itching)
Scratch

What are the existing conditions these people have? *

Parkinson's Disease: 35 people, 58.33%
Hallucinations (sensations that appear real but are created by your mind): 31 people, 51.67%
Delusion (a false belief or opinion): 26 people, 43.33%
Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 6 people, 10.00%
Pain: 4 people, 6.67%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 4 people, 6.67%
Dementia (madness): 4 people, 6.67%
Urinary Tract Infection: 3 people, 5.00%
Nausea And Vomiting: 3 people, 5.00%
Headache (pain in head): 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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