Promethazine and Repatha drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Repatha (evolocumab). Common drug interactions include knee arthroplasty among females and muscle spasms among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Repatha. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

60 people who take Promethazine and Repatha together, and have interactions are studied.

Promethazine and Repatha drug interactions.

What are the common drug interactions of Promethazine and Repatha, by gender? *:

female:

Knee arthroplasty
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)
Pain in extremity
Procedural pain
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tendonitis (a condition that causes pain and swelling of tendons)
Adrenal mass
Angioplasty
Arterial insufficiency (lack of enough blood flow through the arteries)

male:

Muscle spasms (muscle contraction)
Pain
Blood phosphorus increased
Blood urine present
Calculus urethral (stone in urethra)
Chest pain
Chronic kidney disease
Dysstasia (difficulty in standing)
Emotional distress
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)

What are the common drug interactions of Promethazine and Repatha, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Influenza like illness
Muscle spasms (muscle contraction)
Muscle tightness
Pain

50-59:

Asthenia (weakness)
Blood phosphorus increased
Blood urine present
Calculus urethral (stone in urethra)
Dysstasia (difficulty in standing)
Emotional distress
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Gait disturbance
General physical condition
Glycosuria (excretion of glucose into the urine)

60+:

Arthralgia (joint pain)
Chest pain
Therapeutic response decreased (less preventive response)
Wheezing (a high-pitched whistling sound made while you breath)
Chest discomfort
Muscle spasms (muscle contraction)
Epistaxis (bleed from the nose)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 8 people, 13.33%
High Blood Pressure: 7 people, 11.67%
Asthma: 5 people, 8.33%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 8.33%
Headache (pain in head): 5 people, 8.33%
Hiv Infection: 5 people, 8.33%
Weight Decreased: 4 people, 6.67%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 4 people, 6.67%
Blood Pressure Abnormal: 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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