Promethazine and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Soliris (eculizumab). Common drug interactions include vitamin d deficiency among females and hypertensive encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Soliris. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Jul, 05, 2026

65 people who take Promethazine and Soliris together, and have interactions are studied.

Promethazine and Soliris drug interactions.

What are the common drug interactions of Promethazine and Soliris, by gender? *:

female:

Vitamin d deficiency
Blood disorder
Infection
Stress
Dyspnoea (difficult or laboured respiration)
Platelet count decreased
Red blood cell count decreased
Cough
Infusion related reaction
Urinary tract infection

male:

Hypertensive encephalopathy (neurological dysfunction induced by malignant hypertension)
Urticaria (rash of round, red welts on the skin that itch intensely)
Bone marrow failure
Cytomegalovirus gastritis (virus infection of stomach)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Neoplasm malignant (cancer tumour)
Syphilis (sexually transmitted , chronic bacterial disease caused by the spirochete treponema pallidum)
Venous thrombosis (blood clot (thrombus) that forms within a vein)

What are the common drug interactions of Promethazine and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Oropharyngeal pain
Stress
Viral upper respiratory tract infection
Vitamin b12 deficiency
Vitamin d deficiency
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)

30-39:

Dyspnoea exertional (breathlessness or shortness of breath)
Ear infection
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)
Kidney transplant rejection
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oropharyngeal pain
Pyrexia (fever)
Renal transplant

40-49:

Headache (pain in head)
Axillary vein thrombosis (formation of a blood clot in axillary vein)
Blood pressure increased
Dyspnoea (difficult or laboured respiration)
Hypervolaemia (abnormally increased volume of blood)

50-59:

Platelet count decreased
Red blood cell count decreased
White blood cell count decreased
Blood disorder
Breast cancer
Cervix carcinoma (cancer of cervix)
Colon cancer metastatic (cancer of colon spreads to other part of body)
Dehydration (dryness resulting from the removal of water)
Depression
Fatigue (feeling of tiredness)

60+:

Abdominal discomfort
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Infusion related reaction
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Malaise (a feeling of general discomfort or uneasiness)
Oxygen consumption decreased
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Sinusitis (inflammation of sinus)

What are the existing conditions these people have? *

Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 34 people, 52.31%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 17 people, 26.15%
Pain: 10 people, 15.38%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 9 people, 13.85%
Migraine (headache): 5 people, 7.69%
Nausea And Vomiting: 4 people, 6.15%
High Blood Pressure: 4 people, 6.15%
Diabetes: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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