Promethazine and Tracleer drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Tracleer (bosentan). Common drug interactions include dyspnoea among females.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Tracleer. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

On Jul, 06, 2026

37 people who take Promethazine and Tracleer together, and have interactions are studied.

Promethazine and Tracleer drug interactions.

What are the common drug interactions of Promethazine and Tracleer, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Fluid overload (too much fluid in the blood)
Right ventricular failure (right half of the heart fails to work)
Swelling face
Syncope (loss of consciousness with an inability to maintain postural tone)
Arthralgia (joint pain)
Disease progression
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

n/a

What are the common drug interactions of Promethazine and Tracleer, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal distension
Disease progression
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Interstitial lung disease
Joint swelling
Ligament sprain (ligament stretched)
Oedema peripheral (superficial swelling)
Pain in extremity

40-49:

Pneumonia
Headache (pain in head)
Oral mucosal blistering (mouth ulcer)
Pyrexia (fever)
Cardiac failure congestive
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Headache (pain in head)
Hip arthroplasty
Hip fracture
Hypersomnia (excessive daytime sleepiness (eds))
Loss of consciousness
Lower respiratory tract infection
Lymphoma (cancer that begins in immune system cells)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pain
Presyncope

60+:

Dyspnoea (difficult or laboured respiration)
Oxygen saturation decreased
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hypoxia (low oxygen in tissues)
Insomnia (sleeplessness)
Migraine (headache)
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)
Pain in jaw

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 8 people, 21.62%
Diabetes: 4 people, 10.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.81%
Pain: 3 people, 8.11%
Tension Headache: 2 people, 5.41%
Hyperthyroidism (over activity of the thyroid gland): 2 people, 5.41%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 5.41%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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